Completed Grants

“Molecular biology of early-onset Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 1999-2002
Amount: 150,000 €

“Molecular genetics of dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: German Dystonia Foundation
Funding period: 1999-2001
Amount: 8,500 €

“Competence Network Parkinson’s Disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Federal Ministry of Education and Research (BMBF)
Funding period: 2000-2004
Amount: 200,000 €

“Genetics of myoclonus-dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2000-2003
Amount: 100,000 €

“Frequency of Parkin mutations in Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Parkinson Disease Foundation (USA)
Funding Period: 2001-2002
Amount: 30,000 €

“Molecular Etiology of early-onset parkinsonism”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2002-2004
Amount: 250,000 €

“Clinical, genetic, and PET studies of DJ-1-associated early-onset parkinsonism”

Principal Investigator: Christine Klein, MD
Funding Agency: Parkinson Disease Foundation/National Parkinson Foundation (USA)
Funding period: 2003-2004
Amount: 30,000 €

“Molecular and epigenetic investigation of myoclonus-dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2003-2005
Amount: 100,000 €

“Heisenberg Fellowship“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2003-2005
Amount: 131,000 €

“Molecular genetic analysis of dopa-responsive dystonia and penetrance studies”

Principal Investigators: Christine Klein, MD and Katja Lohmann, PhD
Funding Agency: Edith Fröhnert Foundation
Funding period: 2005-2007
Amount: 45,000 €

“W2 Lichtenberg Professorship (Associate professor)“

Principal Investigator: Christine Klein, MD
Funding Angency: Volkswagen Foundation
Funding period: 2005-2010
Amount: 1,300,000 €

“Infrastructure support of the Lichtenberg Grant“

Principal Investigator: Christine Klein, MD
Funding Angency: Possehl Foundation
Funding period: 2005-2011
Amount: 77,000 €

“Scholarship for Eastern European scientists (DYT8 dystonia)”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2005-2006
Amount: 16,300 €

“Genetic risk factors of musician´s dystonia as a special subgroup of focal dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Medical Research Foundation
Funding period: 2006
Amount: 40,000 €

“Impact of mutations in Parkin and PINK1: Endogenous protein function in Parkinson disease”

Principal Investigators: Christine Klein, MD and Norman Kock, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2006-2008
Amount: 140,000 €

„Identifying the genetic etiology of restless legs syndrome”

Principal Investigators: Katja Lohmann, PhD and Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2007-2009
Amount: 160,000 €

“Genomic biomarkers for Parkinson's disease”

Principal Investigator: Christine Klein, MD
Funding Agency: European Commission (EU)
Funding period: 2007-2011
Amount: 440,000 €

“Interdisciplinary Center for Genetic Movement Disorders Lübeck”

Principal Investigator: Christine Klein, MD
Funding Agency: Possehl Foundation
Funding period: 2007-2012
Amount: 388,000 €

“Graduate School for Computing in Medicine and Life Sciences” (GSC 235)

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG Program of Excellence)
Funding period: 2007-2012
Amount: 150,000 €

“The biochemical consequences of the C1366T PINK1 mutation in PD patient and mutation carrier cells”

Principal Investigators: Anthony H.V. Shapira, PhD and Christine Klein, MD
Funding agency: Parkinson's Disease Society UK
Funding period: 2008
Amount: 15,000 €

“Family studies of ATP13A2-associated parkinsonism”

Principal Investigator: Christine Klein, MD
Funding agency: Hilde Ulrichs Foundation for Parkinson’s Disease
Funding period: 2008
Amount: 10,000 €

“Support for the 14. Annual Meeting of the German Society of Neurogenetics in Lübeck“

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2008
Amount: 2,630 €

“Role of the PRKRA (DYT16) gene in dystonia”

Principal Investigator: Christine Klein, MD and Ana Djarmati, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2008-2010
Amount: 102,000 €

”Support of a bilateral collaboration with Pakistan”

Principal Investigator: Prof. Dr. Christine Klein
Funding agency: German Research Foundation (DFG)
Funding period: 2010
Amount: 5,000 €

“Genetic risk factors of musician’s dystonia”

Principal Investigators: Katja Lohmann, PhD, Christine Klein, MD, and Andreas Ziegler, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 295,000 €

“Identification of the mutated genes in two novel forms of hereditary spastic paraplegia”

Principal Investigator: Alfredo Ramirez, PI
Funding Agency: Tom Wahlig Stiftung
Funding period: 2010-2011
Amount: 15,000 €

“The role of Parkin in mitochondrial function and morphology”

Principal Investigator: Anne Grünewald, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 95,000 €

“Parkin-mediated ubiquitination and Parkinson´s disease: Role of ubiquitin-conjugating enzymes (E2s) and ubiquitin-interacting motif (UIM)-containing proteins”

Principal Investigator: Ana Djarmati, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 30,540 €

“Elucidation of the genetic cause of DYT4 using exome sequencing”

Principal Investigator: Christine Klein, MD and Katja Lohmann, PhD
Funding agency: Bachmann Strauss Dystonia [&] Parkinson Foundation
Funding period: 2011
Amount: 35,500 €

“Molecular analysis of the THAP1 gene and its role in dystonia”

Principal Investigator: Katja Lohmann, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2012
Amount: 220,000 €

“Abundance and cellular localization of wildtype and mutant SGCE in human skin fibroblasts and induced pluripotent stem cell‐derived neurons”

Principal Investigator: Anne Grünewald, PhD
Funding agency: Dystonia Medical Research Foundation
Funding period: 2011-2012
Amount: 76,000 €

“Characterization of endophenotypes in focal task-specific dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Coalition (NINDS)
Funding period: 2011-2012
Amount: 35,500 €

“New insights into the genetics and molecular pathways of XDP”

Principal Investigator: Ana Westenberger, PhD
Funding agency: Bachmann-Strauss Dystonia [&] Parkinson Foundation
Funding period: January 2012 to December 2012
Amount: 50,200 €

“Identifizierung und Charakterisierung von genetischen Risikofaktoren der Dystonien”

Principal Investigator: Katja Lohmann, PhD
Funding agency: Renate-Maaß-Foundation
Funding period: 2012
Amount: 5,000 €

“Genomics of Recessive Parkinsonism – NGFN‐plus”

Principal Investigator: Christine Klein, MD
Funding agency: Federal Ministry of Education and Research (BMBF)
Funding period: 2008-2013
Amount: 340,000 €

“Genetic risk factors of musician’s dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2013
Amount: 295,000 €

“Epidemiology of non‐motor symptoms in Parkison disease: Frequency, characteristics, specificity, and course”

Principal Investigator: Meike Kasten, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2013
Amount: 300,000 €

“Transcranial ultrasonographic evaluation of the basal ganglia in DYT1, DYT11, and DYT12 dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: Bachmann-Strauss Dystonia [&] Parkinson Foundation
Funding period: 2012 – 2013
Amount: 20,000 USD

“Modulation of response inhibition mechanisms of action control: a combined TMS-fMRI study in healthy individuals”

Principal Investigator: Norbert Brüggemann, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2011-2013
Amount: 50,000 €

“8th Annual Meeting of GEO-PD (Genetic Epidemiology of Parkinson's Disease) in Lübeck”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2013
Amount: 24,000 €

“Quantitative proteomics approach to elucidate the impairment of mitophagy in a human cellular model of Parkinson´s disease”

Principal Investigator: Ana Djarmati, PhD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2011-2013
Amount: 180,000 €

“The role of the PINK1/Parkin pathway in the regulation of mitophagy”

Principal Investigator: Anne Grünewald, PhD
Funding agency: Fritz Thyssen Foundation
Funding period: 2012 – 2014
Amount: 125,000 €

“Mitochondrial mutations in neurodegenerative diseases”

Principal Investigator: Anne Grünewald, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2012 – 2014
Amount: 54,000 €

 “Gene expression profiling in X-linked dystonia-parkinsonism”

Principal Investigator: Aloysius Domingo, MD
Funding agency: Deutsche Akademischer Austausch Dienst (DAAD)
Funding period: 2014-2015
Amount: 12,000 €

“Schilling Department of Clinical and Molecular Neurogenetics”

Principal Investigator: Christine Klein
Funding agency: Hermann and Lilly Schilling Foundation and Stifterverband für die Deutsche Wissenschaft
Funding period: 2009‐2019
Amount: € 4,450,000

“The role of endogenous Parkin and PINK1 mutations in human dopaminergic neurons” KL1134/11-1

Principal Investigator: Prof. Dr. Christine Klein
Funding agency: German Research Society (DFG)
Funding period: 2012 – 2015
Amount: € 322,642

“StemBANCC; IMI Project on human induced pluripotent stem cells”

Principal Investigator: Christine Klein (WP2)
Funding agency: European Commission (FP7)
Funding period: 2012–2017
Amount: € 794,769

“Generation of a reference cohort with extreme eating behaviour”, SFB134

Principal Investigator: Christine Klein
Funding agency: German Research Foundation (SFB)
Funding period: 2014–2017
Amount: € 250,000

“Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson´s Disease”

Principal Investigator: Christine Klein (WP2)
Funding agency: Federal Ministry of Research and Education (BMBF)
Funding period: 2015–2017
Amount: € 157,600

“MitoPD Mitochondrial endophenotypes of PD” 031A430B

Principal Investigator: Christine Klein
Funding agency: Federal Ministry of Research and Education (BMBF)
Funding period: 2015–2018
Amount: € 1,099,269

„Molecular characterization of TUBB4 mutations”; KL1134/13-1

Principal Investigator: Christine Klein
Funding agency: German Research Society (DFG)
Funding period: 2014–2018
Amount: € 103,800

“Building up a collaborative resource of biomaterials to unravel the genetic cause and molecular pathways of XDP and to enable comprehensive – omics approaches and drug screening”

Principal Investigator: Dr. Christine Klein
Funding agency: Massachusetts General Hospital (CCXDP)
Funding period: 2015–2018
Amount: € 91,340

“DYSTRACT: German Dystonia Registry”

Principal Investigator: Christine Klein
Funding agency: Federal Ministry of Research and Education (BMBF)
Funding period: 2016–2019
Amount: € 886,284

“Establishing a pipeline for individualized CIBD cellular models based on iPSCs”

Principal Investigator: Christine Klein
Funding agency: Cluster of Excellence (DFG)
Funding period: 2017–2018
Amount: € 47,500

“Identifying global cohorts with monogenic Parkinson´s disease”; 15015

Principal Investigator: Christine Klein
Funding agency: The Michael J. Fox Foundation
Funding period: 2018
Amount: US$ 50,312

“Nachwuchsförderung der Deutschen Gesellschaft für Parkinson und Bewegungsstörungen e.V.”

Principal Investigator: Jannik Prasuhn, MD
Funding agency: Deutschen Gesellschaft für Parkinson und Bewegungsstörungen e.V.
Funding period: 2019
Amount: 25,000 €

“Pallidal neurostimulation in XDP”

Principal Investigator: Prof. Dr. Norbert Brüggemann
Funding agency: Collaborative Center for XDP at Massachusetts General Hospital
Funding period: 2015-2020
Amount: 615,124 USD

“SysMedPD: Systems Medicine of Mitochondrial Parkinson`s Disease”

Principal Investigator: Christine Klein
Funding agency: European Commissions (H2020)
Funding period: 2015–2020
Amount: € 672,512.50

“Characterizing global cohorts with monogenic Parkinson´s disease”

Principal Investigator: Christine Klein
Funding agency: The Michael J. Fox Foundation
Funding period: 2018-2020
Amount: US$ 318,674.25

“The Edmond J. Safra Fellowship in Movement Disorders 2018”

Principal Investigator: Christine Klein
Funding agency: The Michael J. Fox Foundation
Funding period: 2018-2020
Amount: US$ 180,000.00

“Novel mitochondrial biomarkers in genetically stratified Parkinson´s disease patients”

Principal Investigator: Christine Klein
Funding agency: The Michael J. Fox Foundation
Funding period: 2018-2020
Amount: US$ 199,750

“Global Parkinson´s Genetcs Program (GP2) – 2020 Working Group Lead”

Principal Investigator: Christine Klein
Funding agency: The Michael J. Fox Foundation
Funding period: 2020
Amount: US$ 25,000

“Global Parkinson´s Genetcs Program (GP2) – 2020 Working Group Lead”

Principal Investigator: Katja Lohmann
Funding agency: The Michael J. Fox Foundation
Funding period: 2020
Amount: US$ 15,000