Completed Grants

“Molecular biology of early-onset Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 1999-2002
Amount: 150,000 €

“Molecular genetics of dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: German Dystonia Foundation
Funding period: 1999-2001
Amount: 8,500 €

“Competence Network Parkinson’s Disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Federal Ministry of Education and Research (BMBF)
Funding period: 2000-2004
Amount: 200,000 €

“Genetics of myoclonus-dystonia“

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2000-2003
Amount: 100,000 €

“Frequency of Parkin mutations in Parkinson’s disease“

Principal Investigator: Christine Klein, MD
Funding Agency: Parkinson Disease Foundation (USA)
Funding Period: 2001-2002
Amount: 30,000 €

“Molecular Etiology of early-onset parkinsonism”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2002-2004
Amount: 250,000 €

“Clinical, genetic, and PET studies of DJ-1-associated early-onset parkinsonism”

Principal Investigator: Christine Klein, MD
Funding Agency: Parkinson Disease Foundation/National Parkinson Foundation (USA)
Funding period: 2003-2004
Amount: 30,000 €

“Molecular and epigenetic investigation of myoclonus-dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2003-2005
Amount: 100,000 €

“Heisenberg Fellowship“

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2003-2005
Amount: 131,000 €

“Molecular genetic analysis of dopa-responsive dystonia and penetrance studies”

Principal Investigators: Christine Klein, MD and Katja Lohmann, PhD
Funding Agency: Edith Fröhnert Foundation
Funding period: 2005-2007
Amount: 45,000 €

“W2 Lichtenberg Professorship (Associate professor)“

Principal Investigator: Christine Klein, MD
Funding Angency: Volkswagen Foundation
Funding period: 2005-2010
Amount: 1,300,000 €

“Infrastructure support of the Lichtenberg Grant“

Principal Investigator: Christine Klein, MD
Funding Angency: Possehl Foundation
Funding period: 2005-2011
Amount: 77,000 €

“Scholarship for Eastern European scientists (DYT8 dystonia)”

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2005-2006
Amount: 16,300 €

“Genetic risk factors of musician´s dystonia as a special subgroup of focal dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Medical Research Foundation
Funding period: 2006
Amount: 40,000 €

“Impact of mutations in Parkin and PINK1: Endogenous protein function in Parkinson disease”

Principal Investigators: Christine Klein, MD and Norman Kock, MD 
Funding Agency: Fritz Thyssen Foundation
Funding period: 2006-2008
Amount: 140,000 €

„Identifying the genetic etiology of restless legs syndrome”

Principal Investigators: Katja Lohmann, PhD and Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2007-2009
Amount: 160,000 €

“Genomic biomarkers for Parkinson’s disease”

Principal Investigator: Christine Klein, MD
Funding Agency: European Commission (EU)
Funding period: 2007-2011
Amount: 440,000 €

“Interdisciplinary Center for Genetic Movement Disorders Lübeck”

Principal Investigator: Christine Klein, MD
Funding Agency: Possehl Foundation
Funding period: 2007-2012
Amount: 388,000 €

“Graduate School for Computing in Medicine and Life Sciences” (GSC 235)

Principal Investigator: Christine Klein, MD
Funding Agency: German Research Foundation (DFG Program of Excellence)
Funding period: 2007-2012 
Amount: 150,000 €

“The biochemical consequences of the C1366T PINK1 mutation in PD patient and mutation carrier cells”

Principal Investigators: Anthony H.V. Shapira, PhD and Christine Klein, MD
Funding agency: Parkinson’s Disease Society UK
Funding period: 2008
Amount: 15,000 €

“Family studies of ATP13A2-associated parkinsonism”

Principal Investigator: Christine Klein, MD
Funding agency: Hilde Ulrichs Foundation for Parkinson’s Disease
Funding period: 2008
Amount: 10,000 €

“Support for the 14. Annual Meeting of the German Society of Neurogenetics in Lübeck“

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2008
Amount: 2,630 €

“Role of the PRKRA (DYT16) gene in dystonia”

Principal Investigator: Christine Klein, MD and Ana Djarmati, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2008-2010
Amount: 102,000 €

”Support of a bilateral collaboration with Pakistan”

Principal Investigator: Prof. Dr. Christine Klein
Funding agency: German Research Foundation (DFG)
Funding period: 2010
Amount: 5,000 €

“Genetic risk factors of musician’s dystonia”

Principal Investigators: Katja Lohmann, PhD, Christine Klein, MD, and Andreas Ziegler, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 295,000 €

“Identification of the mutated genes in two novel forms of hereditary spastic paraplegia”

Principal Investigator: Alfredo Ramirez, PI
Funding Agency: Tom Wahlig Stiftung
Funding period: 2010-2011
Amount: 15,000 €

“The role of Parkin in mitochondrial function and morphology”

Principal Investigator: Anne Grünewald, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 95,000 €

“Parkin-mediated ubiquitination and Parkinson´s disease: Role of ubiquitin-conjugating enzymes (E2s) and ubiquitin-interacting motif (UIM)-containing proteins”

Principal Investigator: Ana Djarmati, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2011
Amount: 30,540 €

“Elucidation of the genetic cause of DYT4 using exome sequencing”

Principal Investigator: Christine Klein, MD and Katja Lohmann, PhD
Funding agency: Bachmann Strauss Dystonia & Parkinson Foundation
Funding period: 2011
Amount: 35,500 €

“Molecular analysis of the THAP1 gene and its role in dystonia”

Principal Investigator: Katja Lohmann, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2010-2012
Amount: 220,000 €

“Abundance and cellular localization of wildtype and mutant SGCE in human skin fibroblasts and induced pluripotent stem cell‐derived neurons”

Principal Investigator: Anne Grünewald, PhD
Funding agency: Dystonia Medical Research Foundation
Funding period: 2011-2012
Amount: 76,000 €

“Characterization of endophenotypes in focal task-specific dystonia”

Principal Investigator: Christine Klein, MD
Funding Agency: Dystonia Coalition (NINDS)
Funding period: 2011-2012
Amount: 35,500 €

“New insights into the genetics and molecular pathways of XDP”

Principal Investigator: Ana Westenberger, PhD
Funding agency: Bachmann-Strauss Dystonia & Parkinson Foundation
Funding period: January 2012 to December 2012
Amount: 50,200 €

“Identifizierung und Charakterisierung von genetischen Risikofaktoren der Dystonien”

Principal Investigator: Katja Lohmann, PhD
Funding agency: Renate-Maaß-Foundation
Funding period: 2012
Amount: 5,000 €

“Genomics of Recessive Parkinsonism – NGFN‐plus”

Principal Investigator: Christine Klein, MD
Funding agency: Federal Ministry of Education and Research (BMBF) 
Funding period: 2008-2013 
Amount: 340,000 €

“Genetic risk factors of musician’s dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG) 
Funding period: 2010-2013 
Amount: 295,000 €

“Epidemiology of non‐motor symptoms in Parkison disease: Frequency, characteristics, specificity, and course”

Principal Investigator: Meike Kasten, MD
Funding agency: German Research Foundation (DFG) 
Funding period: 2010-2013 
Amount: 300,000 €

“Transcranial ultrasonographic evaluation of the basal ganglia in DYT1, DYT11, and DYT12 dystonia”

Principal Investigator: Christine Klein, MD
Funding agency: Bachmann-Strauss Dystonia & Parkinson Foundation
Funding period: 2012 – 2013
Amount: 20,000 USD

“Modulation of response inhibition mechanisms of action control: a combined TMS-fMRI study in healthy individuals”

Principal Investigator: Norbert Brüggemann, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2011-2013
Amount: 50,000 €

“8th Annual Meeting of GEO-PD (Genetic Epidemiology of Parkinson’s Disease) in Lübeck”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2013
Amount: 24,000 €

“Quantitative proteomics approach to elucidate the impairment of mitophagy in a human cellular model of Parkinson´s disease”

Principal Investigator: Ana Djarmati, PhD
Funding Agency: Fritz Thyssen Foundation
Funding period: 2011-2013
Amount: 180,000 €

“The role of the PINK1/Parkin pathway in the regulation of mitophagy”

Principal Investigator: Anne Grünewald, PhD
Funding agency: Fritz Thyssen Foundation
Funding period: 2012 – 2014
Amount: 125,000 €

“Mitochondrial mutations in neurodegenerative diseases”

Principal Investigator: Anne Grünewald, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2012 – 2014
Amount: 54,000 €

“Multidisciplinary X-linked Dystonia-Parkinsonism Workshop”

Principal Investigators: Prof. Dr. Christine Klein, Dr. Aloysius Doming, Dr. Ana Westenberger
Funding agency: Fritz Thyssen Foundation
Funding period: May-June 2014
Amount: 9,700 

“Schilling Department of Clinical and Molecular Neurogenetics”

Principal Investigator: Christine Klein, MD
Funding agency: Hermann and Lilly Schilling Foundation and Stifterverband für die Deutsche Wissenschaft
Funding period: 2009‐2018
Amount: 4,450,000 €

“Multi‐Site Communication in the Brain” (Collaborative Research Center 936)

Co- Principal Investigators (Subproject C5): Alexander Münchau, MD and Christine Klein, MD
Funding Agency: German Research Foundation (DFG)
Funding period: 2011-2015
2015 Amount: 420,000 €

“Identification of targets and interactors of the DYT6-related transcription factor THAP1”

Principal Investigator: Katja Lohmann, PhD
Funding agency: German Research Foundation (DFG)
Funding period: July 2012 to October 2015
Amount: 245,000 €

“The role of endogenous PINK1 and Parkin mutations in human dopaminergic neurons”

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: September 2012 to August 2015
Amount: 322,642 €

“StemBANCC”

Work package leader (W2): Christine Klein, MD
Funding agency: Innovative Medicines Initiative (EU)
Funding period: September 2012 to August 2017
Amount: 794,769 €

“Unraveling novel genetic causes in alcohol-responisive dystonia by exome sequencing”

Principal Investigator: Katja Lohmann, PhD
Funding agency: Dystonia Coalition, NIH
Funding period: 2013-2015
Amount: 49,000 USD

“Gene expression profiling in X-linked dystonia-parkinsonism”

Principal Investigator: Aloysius Domingo, MD
Funding agency: Deutsche Akademischer Austausch Dienst (DAAD)
Funding period: 2014-2015
Amount: 12,000 €

“Understanding molecular mechanisms leading to X-linked dystonia-parkinsonism: Insights from an induced pluripotent stem cell-derived neuronal model”

Principal Investigator: Ana Westenberger, PhD
Funding agency: Fritz Thyssen Foundation
Funding period: 2014-2016
Amount: 100,000 €

“Generation of a reference cohort for extreme eating behaviour” SFB134

Principal Investigator: Christine Klein, MD
Funding agency: Deutsche Forschungsgemeinschaft (DFG)
Funding period: 2014-2017
Amount: 250,000 €

“COmprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson#s Disease (COURAGE-PD)”

Principal Investigator: Christine Klein, MD
Funding agency: Bundesministeriums für Bildung und Forschung (BMBF)
Funding period: 2014-2016
Amount: 157,600 €

Identification of novel dystonia genes in consanguineous families

Principal Investigator: Katja Lohmann, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2014-2016
Amount: 299,177 €

“MitoPD Mitochondrial endophenotypes of PD”

Co-Principal Investigator: Christine Klein, MD
Funding agency: Bundesministeriums für Bildung und Forschung (BMBF)
Funding period: 2015-2018
Amount: 1,099,269 

“Molecular characterization of TUBB4 mutations” KL 1134/13-1

Principal Investigator: Christine Klein, MD
Funding agency: German Research Foundation (DFG)
Funding period: 2014-2017
Amount: 103,800 €

Molecular characterization of TUBB4 mutations” RA 2614/1-1

Principal Investigator: Aleksandar Rakovic, PhD
Funding agency: German Research Foundation (DFG)
Funding period: 2014-2017
Amount: 273,650 €

“Online Tool for Correlations of Genotype and Phenotype“

Principal Investigator: Christine Klein, MD
Funding agency: The International Parkinson and Movement Disorder Society
Funding period: 2014-2017
Amount: 115,200 €

“Pallidal neurostimulation in XDP“

Principal Investigator: Norbert Brüggemann, MD
Funding agency: Collaborative Center for XDP at Massachusetts General Hospital
Funding period: 2014-2017
Amount: 219,000 €

Im Rahmen des Sonderforschungsbereiches (SFB) 134 und anderer Kohorten-Studien suchen wir für die Aufarbeitung von Blutproben 1-2 motivierte und flexible HiWis (max. 45 Stunden/Monat).

Ein Teil der Arbeitszeit wird am Samstag liegen. Vorerfahrung in einem molekulargenetischen Labor (Zentrifugation, Pipettieren) sowie ein Interesse an neurogenetischen Fragestellungen ist erwünscht.

Interessenten melden sich bitte bei Prof. Katja Lohmann (katja.lohmann@neuro.uni-luebeck.de).