Research fellow at the Institute of Neurogenetics, University of Lübeck

Mitochondrial dysfunction (sysmedPD.eu) and reduced penetrance (protect-move.de) in genetic Parkinson’s disease

Education:

10/2009 – 07/2017 Studies in medicine (University of Lübeck, FZ Borstel, Bürgerspital Solothurn (University of Bern))

10/2012 – present Doctoral thesis (in progress) at the Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Topic: The role of specific antigen presenting cells in the pathogenesis of experimental cerebral malaria (ECM)

Scientific training:

08/2017 – present Research fellowship at the Institute of Neurogenetics, University of Lübeck

 
  1. Schiemenz C, Westenberger A, Tanzer K, Grütz K, Borsche M, Mahlke G, Schaake S, Rakovic A, Aherrahrou Z, Erdmann J, Klein C, Alvarez-Fischer D. Osteoclast imbalance in primary familial brain calcification: evidence for its role in brain calcification. Brain 2019;1:e1.
  2. Dulovic-Mahlow M, Lukomska A, Diaw SH, Balck A, Borsche M, Grütz K, Lenz I, Rudolph F, Lohmann K, Klein C, Seibler P. Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson’s disease. Stem Cell Res 2019:101629.
  3. Borsche M, Balck A, Kasten M, Lohmann K, Klein C, Brüggemann N. The sooner, the later – Delayed diagnosis in Parkinson’s disease due to Parkin mutations. Parkinsonism Relat Disord 2019:284-285.
  4. Balck A, Borsche M, Kasten M, Lohmann K, Seibler P, Brüggemann N, Klein C. Discordance in monozygotic Parkinson’s disease twins – continuum or dichotomy? Ann Clin Transl Neurol 2019;6:1102-1105.
  5. Trinh J, Lohmann K, Baumann H, Balck A, Borsche M, Brüggemann N, Dure L, Dean M, Volkmann J, Tunc S, Prasuhn J, Pawlack H, Imhoff S, Lill CM, Kasten M, Bauer P, Rolfs A, International Parkinson’s Disease Genomics Consortium (IPDGC)., Klein C. Utility and implications of exome sequencing in early-onset Parkinson’s disease. Mov Disord 2018;1:133-137.
  6. Borsche M, Hahn S, Hanssen H, Münchau A, Wandinger KP, Brüggemann N. Sez6l2-antibody-associated progressive cerebellar ataxia: a differential diagnosis of atypical parkinsonism. J Neurol 2018;2:522-524.
  7. Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation. Nature 2018;7722:258-262.